GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs30187 | 1 | rs469758 | chr5:96121715 | ERAP1 | chr5:96096515-96149837:- | -0.45 | -5.52 | 1.45E-7 | Ankylosing spondylitis |
| UCEC | cis | rs1577917 | 1 | rs4706254 | chr6:86602813 | SNHG5 | chr6:86386726-86388451:- | -0.45 | -5.74 | 4.91E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs4707239 | chr6:86610717 | SNHG5 | chr6:86386726-86388451:- | -0.46 | -5.96 | 1.65E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs9473555 | 1 | rs4715129 | chr6:49415043 | MUT | chr6:49398994-49431031:- | 0.35 | 5.83 | 3.16E-8 | Folate pathway vitamin levels |
| UCEC | cis | rs9473555 | 1 | rs4715130 | chr6:49416825 | MUT | chr6:49398994-49431031:- | 0.41 | 6.9 | 1.29E-10 | Folate pathway vitamin levels |
| UCEC | cis | rs4728142 | 1 | rs4728142 | chr7:128573967 | IRF5 | chr7:128577769-128590086:+ | 0.38 | 5.5 | 1.59E-7 | Systemic lupus erythematosus;Ulcerative colitis;Inflammatory bowel disease |
| UCEC | cis | rs4812048 | 1 | rs4812048 | chr20:57587771 | CTSZ | chr20:57570242-57582309:- | -0.48 | -4.48 | 1.48E-5 | Mean platelet volume |
| UCEC | cis | rs6534441 | 1 | rs4833988 | chr4:125418536 | ANKRD50 | chr4:125585468-125633887:- | 0.3 | 4.64 | 7.59E-6 | Major depressive disorder |
| UCEC | cis | rs2130392 | 1 | rs4862406 | chr4:185629339 | MLF1IP | chr4:185615220-185655286:- | 0.51 | 8.07 | 1.99E-13 | Kawasaki disease |
| UCEC | cis | rs4869313 | 1 | rs4869313 | chr5:96223880 | ERAP2 | chr5:96211644-96255398:+ | -0.84 | -12.28 | 1.64E-24 | Pediatric autoimmune diseases |
| UCEC | cis | rs12590640 | 1 | rs4898899 | chr14:36850271 | MBIP | chr14:36767764-36789882:- | 0.36 | 4.54 | 1.15E-5 | Malaria |
| UCEC | cis | rs4925325 | 1 | rs4925325 | chr20:60514224 | TAF4 | chr20:60549855-60640866:- | -0.31 | -4.46 | 1.61E-5 | Obesity-related traits |
| UCEC | cis | rs2028299 | 1 | rs4932148 | chr15:90394356 | AP3S2 | chr15:90373832-90456222:- | -0.47 | -4.87 | 2.83E-6 | Type 2 diabetes |
| UCEC | cis | rs10935120 | 1 | rs4955555 | chr3:134286427 | ANAPC13 | chr3:134196547-134204865:- | 0.41 | 4.69 | 6.01E-6 | Height |
| UCEC | cis | rs9815354 | 1 | rs4973991 | chr3:41927273 | ULK4 | chr3:41288091-42003660:- | -0.52 | -6.41 | 1.75E-9 | Diastolic blood pressure |